Abstract Background Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian function before the age of 40 years. characterized by elevated serum gonadotropin levels and decreased estrogen levels with menstrual disturbance. POI can be natural or iatrogenic such as after chemotherapy. radiotherapy and surgery. https://lecoureures.shop/product-category/ski-de-fond-accessoires-fixations/