We consider cancer cytotoxic drugs as an optimal control problem to stabilize a heterogeneous tumor by attacking not the most abundant cancer cells. but those that are crucial in the tumor ecosystem. We propose a mathematical cancer stem cell model that translates the hierarchy and heterogeneity of cancer cell types by including highly structured tumorigenic cancer stem cells that yie... https://www.missouriquiltcoes.shop/product-category/yardage-patterns/